Subcutaneous botulinum toxin type a injection for chronic medial knee pain with ostheoarthritis
Anesthesia and Pain Medicine
;
: 221-225, 2009.
Artículo
en Inglés
| WPRIM
| ID: wpr-143708
ABSTRACT
BACKGROUND:
This study was designed to evaluate the efficacy of subcutaneous Botulinum toxin type A (BoNT-A) injection for treating chronic medial knee pain with osteoarthritis.METHODS:
A randomized, double-blind, placebo-controlled clinical trial was conducted at a university hospital in Korea.The subjects suffering from chronic medial knee pain with osteoarthritis were randomly allocated to either the BoNT-A (treatment, n = 23) group or the normal saline (placebo, n = 27) group.Injections were given to 10 points per unilateral knee along the course of the saphenous nerve.A total of 90 units of BoNT-A (60 units at baseline and 30 units after 1 week) was given for treating unilateral knee pain and a total of 180 units of BoNT-A was given for treating bilateral knee pain.The placebo group received the same volume of normal saline.RESULTS:
The Visual Analog Scale (VAS) pain score was significantly decreased in both the BoNT-A and normal saline groups 1, 4 and 12 weeks after injection.After adjusting for covariates, BoNT-A had a 0.788 times higher effect to decrease the VAS score than did normal saline, but the effect was marginally significant (P = 0.050).CONCLUSIONS:
Subcutaneous injection along the course of the saphenous nerve significantly reduces chronic medial knee pain. The pain reduction effect of BoNT-A is higher than that of placebo, but the effect is marginally significant
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Osteoartritis
/
Estrés Psicológico
/
Toxinas Botulínicas
/
Toxinas Botulínicas Tipo A
/
Rodilla
Tipo de estudio:
Ensayo Clínico Controlado
Idioma:
Inglés
Revista:
Anesthesia and Pain Medicine
Año:
2009
Tipo del documento:
Artículo
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