A Case of Renal Transplantation in A Patient with Fabry's Disease / 대한이식학회지
The Journal of the Korean Society for Transplantation
;
: 111-116, 1998.
Artículo
en Coreano
| WPRIM
| ID: wpr-144154
ABSTRACT
Fabry's disease is a rare, inborn error, sex-linked disorder of glycosphingolipid metabolism with death occurring from myocardial or renal involvement at 4th or 5th decades. The primary metabolic defect lies in the deficient tissue activity of the enzyme alpha-galactosidase A which results in progressive accumulation of the specific neutral glycosphingolipids, cerebroside dihexoside(CDH) and cerebroside triihexoside(CTH), within the lysosomes of endothelial, perithelial and smooth muscle cells of the cardiovascular and renal systems predominantly. Clinical manifestations are sequelae of the anatomic and physiologic alterations produced by the progressive deposition of glycosphingolipid in the tissues. We report the first case of successful renal transplantation in a patient with Fabry's disease in Korea. The patient was a 33-year-old male. Fabry's disease was confirmed by measurement of serum alpha- galactosidase level and renal biopsy. Biopsy finding showed lamellar inclusion bodies on electron microscopy. Galactosidase activity was also markedly decreased. He has been well for 49 months.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Trasplante
/
Biopsia
/
Microscopía Electrónica
/
Cuerpos de Inclusión
/
Trasplante de Riñón
/
Enfermedad de Fabry
/
Alfa-Galactosidasa
/
Glicoesfingolípidos Neutros
/
Miocitos del Músculo Liso
/
Galactosidasas
Límite:
Adulto
/
Humanos
/
Masculino
País/Región como asunto:
Asia
Idioma:
Coreano
Revista:
The Journal of the Korean Society for Transplantation
Año:
1998
Tipo del documento:
Artículo
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