Outcomes of Second-Line Chemotherapy for Advanced Non-Small Cell Lung Cancer in One Institution / 결핵및호흡기질환
Tuberculosis and Respiratory Diseases
;
: 13-17, 2014.
Artículo
en Inglés
| WPRIM
| ID: wpr-144985
ABSTRACT
BACKGROUND:
This study analyzed the negative prognostic factors in patients who received second-line chemotherapy for advanced inoperable non-small cell lung cancer (NSCLC).METHODS:
We retrospectively reviewed the records of 137 patients with inoperable stage III-IV NSCLC who received second-line chemotherapy. The effects of clinical parameters on survival were analyzed and the hazard ratios (HR) for mortality were identified by a Cox regression analysis.RESULTS:
Sex, age older than 65 years, smoking history, cell type, T-stage, best response to first-line chemotherapy and first-line chemotherapy regimen were significant negative predictors in univariate analysis. The multivariate analysis showed that patients older than 65 years (HR, 1.530; 95% confidence interval [CI], 1.020-2.297), advanced T stage (T4 vs. T1; HR, 2.273; 95% CI, 1.010-5.114) and non-responders who showed progression with first-line chemotherapy (HR, 1.530; 95% CI, 1.063-2.203) had higher HR for death.CONCLUSION:
The age factor, T stage and responsiveness to first-line chemotherapy were important factors in predicting the outcome of patients with advanced NSCLC who received second-line chemotherapy. The results may help to predict outcomes for these patients in the future.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Humo
/
Fumar
/
Análisis Multivariante
/
Estudios Retrospectivos
/
Mortalidad
/
Factores de Edad
/
Carcinoma de Pulmón de Células no Pequeñas
/
Quimioterapia
Tipo de estudio:
Estudio observacional
/
Estudio pronóstico
Límite:
Humanos
Idioma:
Inglés
Revista:
Tuberculosis and Respiratory Diseases
Año:
2014
Tipo del documento:
Artículo
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