Loss of Caveolin 1 is Associated With the Expression of Aquaporin 1 and Bladder Dysfunction in Mice / 대한배뇨장애요실금학회지
International Neurourology Journal
; : 34-38, 2015.
Article
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| ID: wpr-145430
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ABSTRACT
PURPOSE: It is suggested that caveolin and aquaporin might be closely associated with bladder signal activity. We investigated the effect of the deletion of caveolin 1, using caveolin 1 knockout mice, on the expression of aquaporin 1 in order to identify their relation in the urothelium of the urinary bladder. METHODS: The cellular localization and expressions of aquaporin 1 and caveolin 1, in the wild type and caveolin 1 knockout mice urinary bladder, were examined by Western blot and immunofluorescence techniques. RESULTS: Aquaporin 1 and caveolin 1 were coexpressed in the arterioles, venules, and capillaries of the suburothelial layer in the wild type controls. Aquaporin 1 protein expression was significantly higher in the caveolin 1 knockout mice than in the wild type controls (P <0.05). CONCLUSIONS: The results imply that aquaporin 1 and caveolin 1 may share a distinct relation with the bladder signal activity. This might play a specific role in bladder dysfunction.
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WPRIM
Asunto principal:
Arteriolas
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Vénulas
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Vejiga Urinaria
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Capilares
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Western Blotting
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Técnica del Anticuerpo Fluorescente
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Ratones Noqueados
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Urotelio
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Caveolina 1
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Acuaporina 1
Límite:
Animals
Idioma:
En
Revista:
International Neurourology Journal
Año:
2015
Tipo del documento:
Article