Delay in Normalization of Disrupted Sleep-Wake Cycle in Mice as a Bipolar Disorder-Prone Animal Model (Bipolar Disorder-Prone Animal Model) / 신경정신의학
Journal of Korean Neuropsychiatric Association
;
: 209-214, 2016.
Artículo
en Coreano
| WPRIM
| ID: wpr-146694
ABSTRACT
OBJECTIVES:
This study was designed to test the hypothesis that delayed recovery from disrupted circadian rhythm is associated with both manic and depressive episodes in bipolar disorder.METHODS:
Twenty-two male mice (age of five weeks, weight 28–30 gm) underwent three days of light-dark cycle disruption and 10 days of recovery phase. Sleep and wake state were checked every five minutes during the entire experimental period. After recovery phase, quinpirole (0.5 mg/kg, s.c.) was injected into the mice and open field locomotor activities were checked. Five days after the open field test, immobility time during the last 4 min in 6 min of forced swimming test was measured. Animals which recovered sleep-wake cycle within six days after light-dark cycle disruption were assigned to the early recovery group (n=14), and those that failed to recover in six days were assigned to the delayed recovery group (n=8). The locomotor activities and the immobility times of the two groups were compared by Mann-Whiney U test at two-tailed significance level of 0.05.RESULTS:
The locomotor activities of the delayed recovery group were higher (mean rank=16.19) than those of the early recovery group (mean rank=8.82, U=18.5, p=0.008). The immobility times did not differ by recovery time (U=32.0 p=0.110).CONCLUSION:
The results suggest that delayed recovery from circadian rhythm disruption raises the risk of manic symptoms rather than depressive symptoms.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Trastorno Bipolar
/
Ritmo Circadiano
/
Fotoperiodo
/
Quinpirol
/
Modelos Animales
/
Depresión
/
Esfuerzo Físico
/
Actividad Motora
Límite:
Animales
/
Humanos
/
Masculino
Idioma:
Coreano
Revista:
Journal of Korean Neuropsychiatric Association
Año:
2016
Tipo del documento:
Artículo
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