Effects of N-acetylcysteine and Methylprednisolone on Lung Injury in a Paraquat-Poisoned Rat Model
Journal of the Korean Society of Emergency Medicine
;
: 214-221, 2001.
Artículo
en Coreano
| WPRIM
| ID: wpr-147057
ABSTRACT
BACKGROUND:
This study evaluated the inhibitory effects of N-acetylcysteine(NAC) and methylprednisolone on lung injury in the paraquat-poisoned rat model.METHODS:
Sixty rats were divided into four groups(n=15 in each group) accordingly to the drug administered group I, only intraperitoneally injected paraquat (20 mg/kg); group II, intraperitoneally injected paraquat and NAC(300 mg/kg); group III, intraperitoneally injected paraquat and methylprednisolone(60 mg/kg); and group IV, intraperitoneally injected paraquat, NAC(300 mg/kg), and methylprednisolone(60 mg/kg). On the 7th day after injection, the survival rate of experimental rats and the positive area of collagen fiber in the injured lung stained by Masson's trichrome were evaluated.RESULTS:
1. There were no differences in the 7-day survival rates for the four groups. 2. The percent of collagen fiber for group II(6.3+/-4.7%) was significantly decreased in comparison with that for group I (14.4+/-9.7%). 3. The percent of collagen fiber for Group III(13.2+/-5.9%) was not significantly different from that for group I(14.4+/-9.7%). 4. The percent of collagen fiber for Group IV(6.9+/-4.6%) was significantly decreased in comparison with that for group I, but was not different from that for group II.CONCLUSION:
These results suggest that NAC protects against pulmonary fibrosis in paraquat-poisoned rats whereas methylprednisolone does not protect against pulmonary fibrosis.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Paraquat
/
Acetilcisteína
/
Fibrosis Pulmonar
/
Metilprednisolona
/
Tasa de Supervivencia
/
Colágeno
/
Modelos Animales
/
Lesión Pulmonar
/
Pulmón
Límite:
Animales
Idioma:
Coreano
Revista:
Journal of the Korean Society of Emergency Medicine
Año:
2001
Tipo del documento:
Artículo
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