Gephyrin: a central GABAergic synapse organizer
Experimental & Molecular Medicine
;
: e158-2015.
Artículo
en Coreano
| WPRIM
| ID: wpr-147140
ABSTRACT
Gephyrin is a central element that anchors, clusters and stabilizes glycine and gamma-aminobutyric acid type A receptors at inhibitory synapses of the mammalian brain. It self-assembles into a hexagonal lattice and interacts with various inhibitory synaptic proteins. Intriguingly, the clustering of gephyrin, which is regulated by multiple posttranslational modifications, is critical for inhibitory synapse formation and function. In this review, we summarize the basic properties of gephyrin and describe recent findings regarding its roles in inhibitory synapse formation, function and plasticity. We will also discuss the implications for the pathophysiology of brain disorders and raise the remaining open questions in this field.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Unión Proteica
/
Sinapsis
/
Proteínas Portadoras
/
Procesamiento Proteico-Postraduccional
/
Regulación de la Expresión Génica
/
Transporte de Proteínas
/
Susceptibilidad a Enfermedades
/
Dominios y Motivos de Interacción de Proteínas
/
Neuronas GABAérgicas
/
Proteínas de la Membrana
Límite:
Animales
/
Humanos
Idioma:
Coreano
Revista:
Experimental & Molecular Medicine
Año:
2015
Tipo del documento:
Artículo
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