Investigation of the Bovine Leukemia Virus Proviral DNA in Human Leukemias and Lung cancers in Korea
Journal of Korean Medical Science
;
: 603-606, 2005.
Artículo
en Inglés
| WPRIM
| ID: wpr-147619
ABSTRACT
The bovine leukemia virus (BLV) is the causative agent of enzootic bovine leucosis. This study investigated the presence of the BLV in leukemia (179 acute lymphoblastic leukemia, 292 acute myeloid leukemia and 46 chronic myelogenous leukemia cases) and 162 lung cancer patients (139 adenocarcinoma, 23 squamous cell carcinoma) to determine if the BLV is a causative organism of leukemia and lung cancer in Koreans. A BLV infection was confirmed in human cells by PCR using a BLV-8 primer combination. All 517 cases of human leukemia and 162 lung cancer were negative for a PCR of the BLV proviral DNA. In conclusion, although meat has been imported from BLV endemic areas, the BLV infection does not appear to be the cause of human leukemia or lung cancer in Koreans. These results can be used as a control for further studies on the BLV in Koreans.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
ADN Viral
/
Leucemia Mielógena Crónica BCR-ABL Positiva
/
Adenocarcinoma
/
Leucemia
/
Leucemia Mieloide
/
Línea Celular
/
Reacción en Cadena de la Polimerasa
/
Enfermedad Aguda
/
Provirus
/
Virus de la Leucemia Bovina
Límite:
Humanos
País/Región como asunto:
Asia
Idioma:
Inglés
Revista:
Journal of Korean Medical Science
Año:
2005
Tipo del documento:
Artículo
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