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Saline-Enhanced Radiofrequency Thermal Ablation of the Lung: A Feasibility Study in Rabbits
Korean Journal of Radiology ; : 245-253, 2002.
Artículo en Inglés | WPRIM | ID: wpr-147900
ABSTRACT

OBJECTIVE:

To assess the feasibility and safety of CT-guided percutaneous transthoracic radiofrequency ablation (RFA) with saline infusion of pulmonary tissue in rabbits. MATERIALS AND

METHODS:

Twenty-eight New Zealand White rabbits were divided into two groups an RFA group (n=10) and a saline-enhanced RFA (SRFA) group (n=18). In the RFA group, percutaneous RFA of the lung was performed under CT guidance and using a 17-gauge internally cooled electrode. In the SRFA group, 1.5 ml of 0.9% saline was infused slowly through a 21-gauge, polyteflon-coated Chiba needle prior to and during RFA. Lesion size and the healing process were studied in rabbits sacrificed at times from the day following treatment to three weeks after, and any complications were noted.

RESULTS:

In the SRFA group, the mean diameter (12.5+/-1.6 mm) of acute RF lesions was greater than that of RFA lesions (8.5+/-1.4 mm) (p < .05). The complications arising in 12 cases were pneumothorax (n=8), thermal injury to the chest wall (n=2), hemothorax (n=1), and lung abscess (n=1). Although procedure-related complications tended to occur more frequently in the SRFA group (55.6%) than in the RFA group (20%), the difference was not statistically significant (p = .11).

CONCLUSION:

Saline-enhanced RFA of pulmonary tissue in rabbits produces more extensive coagulation necrosis than conventional RFA procedures, without adding substantial risk of serious complications.
Asunto(s)

Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Cloruro de Sodio / Tomografía Computarizada por Rayos X / Ablación por Catéter / Pulmón / Neoplasias Pulmonares / Animales Tipo de estudio: Guía de Práctica Clínica Límite: Animales Idioma: Inglés Revista: Korean Journal of Radiology Año: 2002 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Cloruro de Sodio / Tomografía Computarizada por Rayos X / Ablación por Catéter / Pulmón / Neoplasias Pulmonares / Animales Tipo de estudio: Guía de Práctica Clínica Límite: Animales Idioma: Inglés Revista: Korean Journal of Radiology Año: 2002 Tipo del documento: Artículo