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Galangin Activates the ERK/AKT-Driven Nrf2 Signaling Pathway to Increase the Level of Reduced Glutathione in Human Keratinocytes
Biomolecules & Therapeutics ; : 427-433, 2017.
Artículo en Inglés | WPRIM | ID: wpr-147982
ABSTRACT
Previously, we demonstrated that galangin (3,5,7-trihydroxyflavone) protects human keratinocytes against ultraviolet B (UVB)-induced oxidative damage. In this study, we investigated the effect of galangin on induction of antioxidant enzymes involved in synthesis of reduced glutathione (GSH), and investigated the associated upstream signaling cascades. By activating nuclear factor-erythroid 2-related factor (Nrf2), galangin treatment significantly increased expression of glutamate-cysteine ligase catalytic subunit (GCLC) and glutathione synthetase (GSS). This activation of Nrf2 depended on extracellular signal-regulated kinases (ERKs) and protein kinase B (AKT) signaling. Inhibition of GSH in galangin-treated cells attenuated the protective effect of galangin against the deleterious effects of UVB. Our results reveal that galangin protects human keratinocytes by activating ERK/AKT-Nrf2, leading to elevated expression of GSH-synthesizing enzymes.
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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Queratinocitos / Dominio Catalítico / Quinasas MAP Reguladas por Señal Extracelular / Proteínas Proto-Oncogénicas c-akt / Glutamato-Cisteína Ligasa / Glutatión / Glutatión Sintasa Límite: Humanos Idioma: Inglés Revista: Biomolecules & Therapeutics Año: 2017 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Queratinocitos / Dominio Catalítico / Quinasas MAP Reguladas por Señal Extracelular / Proteínas Proto-Oncogénicas c-akt / Glutamato-Cisteína Ligasa / Glutatión / Glutatión Sintasa Límite: Humanos Idioma: Inglés Revista: Biomolecules & Therapeutics Año: 2017 Tipo del documento: Artículo