The Significance of the Lymphatic Micro Vessel Density and Vascular Endothelial Growth Factor- C Expression for Colorectal Cancer
Journal of the Korean Surgical Society
;
: 406-411, 2007.
Artículo
en Coreano
| WPRIM
| ID: wpr-148067
ABSTRACT
PURPOSE:
Studying the prognostic factors of distant metastasis is quite important for predicting these patients' prognosis and also for providing standards for post-operative adjuvant chemotherapy. Microbiological studies currently enable researchers to look for new predictors of distant metastasis in patients with colon cancers. In this study, the VEGF-C expression and stain rate of D2-40 were investigated as prognostic factors.METHODS:
79 Specimens were collected from the patients who underwent colorectal operation and they were pathologicaly diagnosed with cancer at Chung-Ang University hospital from March, 2003 to Sept. 2005. The specimens were immunohistochemically stained to detect the VEGF-c expression and the D2- 40 stain rate.RESULTS:
The VEGF-C expression was related to lymph node metastasis, tumor embolism and the frequency of the T- stage, but it was not related to progression of cancer. The D2-40 stained lymphatic density was significantly increased in the cases with lymph node metastasis and in the tumor embolism cases; furthermore, the density became higher in relation to the increased T-stage and progression of cancer.CONCLUSION:
The VEGF-C expression and lymphatic vessel density appear to be prognostic factors for colon cancer.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Pronóstico
/
Neoplasias Colorrectales
/
Quimioterapia Adyuvante
/
Neoplasias del Colon
/
Vasos Linfáticos
/
Factor C de Crecimiento Endotelial Vascular
/
Ganglios Linfáticos
/
Células Neoplásicas Circulantes
/
Metástasis de la Neoplasia
Tipo de estudio:
Guía de Práctica Clínica
/
Estudio pronóstico
Límite:
Humanos
Idioma:
Coreano
Revista:
Journal of the Korean Surgical Society
Año:
2007
Tipo del documento:
Artículo
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