Statistical Analysis of 1,000 Cases of Kawasaki Disease Patients Diagnosed at a Single Institute / 소아과
Korean Journal of Pediatrics
;
: 416-424, 2005.
Artículo
en Coreano
| WPRIM
| ID: wpr-148991
ABSTRACT
PURPOSE:
To find the risk factors associated with coronory artery lesions, non-responsiveness to intravenous immunoglobulin(IVIG) treatment, and recurrences in Kawasaki disease patients.METHODS:
We retrospectively analyzed 1,000 Kawasaki disease patients who were admitted to Yonsei University Medical Center from September 1990 to December 2003. We compared between responder and non-responder groups to IVIG treatment as well as between relapsed and non-relapsed groups, and as to the relapsed group, we also compared variables between patients in their first and second attack states. Finally, factors associated with longer-fever duration from disease onset were evaluated.RESULTS:
Longer fever durations before and after IVIG treatment, male sex, lower Hgb and Hct level, higher WBC count and segmented WBC proportion, and higher CRP and Harada's score were related with coronary artery lesions. Non-responsiveness was related to higher WBC count, segmented WBC proportion, CRP, SGPT, Harada's score, and pyuria. Moderate-to-severe coronary artery dilatations and recurrences were more commonly seen among the non-responder group. No significant predictive factors for recurrence were found. In the relapsed group, lower WBC count, CRP, and shorter fever duration from disease onset were observed in their second attack state. Fever duration from disease onset showed positive correlation with WBC count, CRP, and Harada's score and negative correlation with Hgb levels.CONCLUSION:
Higher WBC count, CRP, and higher Harada's score were related to both higher incidences of coronary artery lesions and non-responsiveness to IVIG treatment, and these factors were also related with longer fever duration. Non-responders to IVIG treatment showed higher recurrence rate and more moderate-to-severe coronary artery dilatations than responders.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Arterias
/
Piuria
/
Recurrencia
/
Incidencia
/
Estudios Retrospectivos
/
Factores de Riesgo
/
Resultado del Tratamiento
/
Inmunoglobulinas Intravenosas
/
Insuficiencia del Tratamiento
/
Vasos Coronarios
Tipo de estudio:
Estudio diagnóstico
/
Estudio de etiología
/
Estudio de incidencia
/
Estudio observacional
/
Estudio pronóstico
/
Factores de riesgo
Límite:
Humanos
/
Masculino
Idioma:
Coreano
Revista:
Korean Journal of Pediatrics
Año:
2005
Tipo del documento:
Artículo
Similares
MEDLINE
...
LILACS
LIS