Onion peel water extracts enhance immune status in forced swimming rat model / 한국실험동물학회지
Laboratory Animal Research
; : 161-168, 2014.
Article
en En
| WPRIM
| ID: wpr-149033
Biblioteca responsable:
WPRO
ABSTRACT
Onion peel contains a high concentration of quercetin and other flavonoids. In this study, the potential immune-enhancing effects of an onion peel water extract (OPE) supplement were investigated by the rat forced swimming test. OPE was prepared using hot water. Thirty-six male Sprague Dawley rats were fed a pellet diet for 1 week and were then randomly divided into six groups: normal control (NC), forced swimming control (FSC), positive control (quercetin 20 mg/kg), and three groups administered 4, 20, or 100 mg/kg of OPE. Oral drug administration was conducted daily for 4 weeks. All rats, except those of NC group, were forced to swim in water and were considered exhausted when they failed to rise to the water surface to breathe within a 7-s period. Blood lymphocyte counts, immune organ weights, histopathological analysis, and serum interferon (IFN)-gamma, tumor necrosis factor (TNF)-alpha, and interleukin (IL)-12 levels were determined. OPE-treated rats consumed more food and had an increased thymic cortex to medulla ratio than that observed in FSC group rats (P<0.05). The area of the white pulp in the spleens of OPE-treated group rats was increased compared with that in FSC group rats (P<0.05). Furthermore, blood lymphocyte numbers and IFN-gamma, TNF-alpha, and IL-12 concentrations were significantly higher in OPE-fed groups than in FSC group (P<0.05). These results suggest that an OPE supplement can improve the immune status by increasing the number of immune-related cells and specific cytokine levels.
Palabras clave
Texto completo:
1
Índice:
WPRIM
Asunto principal:
Tamaño de los Órganos
/
Quercetina
/
Bazo
/
Natación
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Flavonoides
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Agua
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Administración Oral
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Citocinas
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Interleucinas
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Interferones
Tipo de estudio:
Prognostic_studies
Límite:
Animals
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Humans
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Male
Idioma:
En
Revista:
Laboratory Animal Research
Año:
2014
Tipo del documento:
Article