Effect of Rheumatoid Factor on Vascular Stiffness in General Population without Joint Symptoms / 고신대학교의과대학학술지
Kosin Medical Journal
;
: 25-35, 2017.
Artículo
en Inglés
| WPRIM
| ID: wpr-149284
ABSTRACT
OBJECTIVES:
The role of rheumatoid factor (RF) in vascular stiffness and cardiovascular risk in subjects without joint symptoms remains unclear. We investigated vascular stiffness in subjects without joint symptoms using pulse wave velocity (PWV), calculated Framingham risk scores (FRS), an estimator of cardiovascular risk, and analyzed whether vascular stiffness and FRS were affected by RF.METHODS:
Two hundred forty-two subjects were included in this population-based study. RF was quantified with turbid immunometry using a cut-off of RF > 15 IU/ml to denote RF positivity. Information was then obtained on joint symptoms. Brachial-ankle PWV (baPWV) was measured using an automated device.RESULTS:
Of the 242 subjects, 15 were RF-positive. RF-positive subjects without joint symptoms had a higher baPWV and FRS than RF-negative subjects without joint symptoms, but the difference did not reach statistical significance. However, when we stratified the subjects into two groups (group A – high RF RF ≥ 40 IU/ml; group B – low RF RF < 40 IU/ml), group A showed significantly higher baPWV (1640.7 ± 179.6 ㎝/s vs. 1405.7 ± 225.7 ㎝/s, P = 0.008) and FRS (25.7 ± 4.87 vs. 11.8 ± 9.6, P < 0.001). Multiple regression analysis was used to examine potential confounders, and RF exhibited significant but modest effects on baPWV (adjusted R-squared = 0.038, P = 0.030).CONCLUSIONS:
In a sample of the general population without joint symptoms, higher levels of RF were associated with increased vascular stiffness, suggesting a pathophysiologic link between RF and endothelial dysfunction.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Factor Reumatoide
/
Rigidez Vascular
/
Análisis de la Onda del Pulso
/
Articulaciones
Tipo de estudio:
Estudio diagnóstico
Idioma:
Inglés
Revista:
Kosin Medical Journal
Año:
2017
Tipo del documento:
Artículo
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