The antibacterial effect of fatty acids on Helicobacter pylori infection
The Korean Journal of Internal Medicine
;
: 30-35, 2016.
Artículo
en Inglés
| WPRIM
| ID: wpr-149378
ABSTRACT
Eradication of Helicobacter pylori is recommended for the management of various gastric diseases, including peptic ulcers and mucosa-associated lymphoid tissue lymphoma. Because of the increasing prevalence of antibiotic resistance, the eradication rates of antibiotic-based therapies have decreased. Therefore, alternative treatments should be considered. The antibacterial properties of fatty acids (FAs) have been investigated in various organisms, including H. pylori. Some FAs, particularly polyunsaturated FAs, have been shown to have bactericidal activity against H. pylori in vitro; however, their antibacterial effects in vivo remain controversial. Poor solubility and delivery of FAs may be important reasons for this discrepancy. Recently, a series of studies demonstrated the antibacterial effects of a liposomal formulation of linolenic acid against H. pylori, both in vitro and in vivo. Further research is needed to improve the bioavailability of FAs and apply them in clinical use.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Helicobacter pylori
/
Infecciones por Helicobacter
/
Resultado del Tratamiento
/
Sistemas de Liberación de Medicamentos
/
Ácidos Grasos
/
Liposomas
/
Antibacterianos
Límite:
Animales
/
Humanos
Idioma:
Inglés
Revista:
The Korean Journal of Internal Medicine
Año:
2016
Tipo del documento:
Artículo
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