Non-Alcoholic Fatty Liver Disease: The Emerging Burden in Cardiometabolic and Renal Diseases
Diabetes & Metabolism Journal
;
: 430-437, 2017.
Artículo
en Inglés
| WPRIM
| ID: wpr-149584
ABSTRACT
As the number of individuals with non-alcoholic fatty liver disease (NAFLD) has increased, the influence of NAFLD on other metabolic diseases has been highlighted. Accumulating epidemiologic evidence indicates that NAFLD not only affects the liver but also increases the risk of extra-hepatic diseases such as type 2 diabetes mellitus, metabolic syndrome, dyslipidemia, hypertension, cardiovascular or cerebrovascular diseases, and chronic kidney disease. Non-alcoholic steatohepatitis, an advanced type of NAFLD, can aggravate these inter-organ relationships and lead to poorer outcomes. NAFLD induces insulin resistance and exacerbates systemic chronic inflammation and oxidative stress, which leads to organ dysfunction in extra-hepatic tissues. Although more research is needed to identify the pathophysiological mechanisms and causal relationship between NAFLD and cardiometabolic and renal diseases, screening for heart, brain, and kidney diseases, risk assessment for diabetes, and a multidisciplinary approach for managing these patients should be highly encouraged.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Arritmias Cardíacas
/
Encéfalo
/
Resistencia a la Insulina
/
Trastornos Cerebrovasculares
/
Tamizaje Masivo
/
Medición de Riesgo
/
Estrés Oxidativo
/
Accidente Cerebrovascular
/
Diabetes Mellitus
/
Diabetes Mellitus Tipo 2
Tipo de estudio:
Estudio de etiología
/
Factores de riesgo
/
Estudio de tamizaje
Límite:
Humanos
Idioma:
Inglés
Revista:
Diabetes & Metabolism Journal
Año:
2017
Tipo del documento:
Artículo
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