Effects of Dexamethasone on expressions of IFN-gamma and IL-4 by PBMCs in response to IL-12 / 나학회지
Korean Leprosy Bulletin
;
: 3-12, 2002.
Artículo
en Coreano
| WPRIM
| ID: wpr-149977
ABSTRACT
Dexamethasone is a widely used anti-inflammatory agent for a broad spectrum of diseases. The effectiveness of this agent is thought to be due to the capacity to modulate cytokine production in inflammatory cells. We examined the effects of dexamethasone on expressions of interferon gamma (IFN-gamma) and interleukin 4 (IL-4) by human peripheral blood mononuclear cells (PBMCs) in response to interleukin 12 (IL-12). Dexamethasone (10-5 M) inhibited IFN-gamma secretion, through direct suppression of IFN-gamma, IL-12 receptor (IL-12R) -beta1, and -beta2 expressions. Conversely dexamethasone increased IL-4 secretion as well as IL-4 expressions by PBMCs in response to IL-12. In addition, dexamethasone increased expression of suppressor of cytokine signalling (SOCS)-1, which inhibits JAK-STAT pathway of IL-12R signalling. The result of our study suggested that dexamethasone directly inhibited IFN-gamma expression, through suppression of IL-12 signalling and indirectly increases IL-4 expression, through suppression of IFN-gamma expression.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Dexametasona
/
Interferones
/
Interleucina-4
/
Interleucina-12
/
Receptores de Interleucina-12
Límite:
Humanos
Idioma:
Coreano
Revista:
Korean Leprosy Bulletin
Año:
2002
Tipo del documento:
Artículo
Similares
MEDLINE
...
LILACS
LIS