Risk Factors for Post-Lumbar Puncture Headache in a Study of Alzheimer's Disease Biomarkers
Dementia and Neurocognitive Disorders
;
: 12-16, 2015.
Artículo
en Inglés
| WPRIM
| ID: wpr-150107
ABSTRACT
BACKGROUND AND PURPOSE:
In memory clinics, the lumbar puncture (LP) is increasingly being used to evaluate cerebrospinal fluid for biomarkers of Alzheimer's disease (AD). Post-lumbar puncture headache (PLPH) is the most frequent complication of LP, and can prove to be a barrier for the performance of LP.METHODS:
We retrospectively collected data from 59 subjects (patients with AD and cognitively healthy controls) who were enrolled in a study aimed to identify AD biomarkers via LP. In order to determine whether subjects experienced PLPH, we assessed recorded follow-up telephone interviews. To analyze the association between the occurrence of PLPH and several demographic- and procedure-related factors, a multiple logistic regression analysis with backward stepwise method was performed.RESULTS:
The overall frequency of PLPH was 49.15%. PLPH was more frequent in younger subjects and clinical diagnosis was associated with PLPH. The use of cutting-edge needles was also suggested as a statistically significant factor in the development of PLPH, and was determined to be the only factor that could be modified in order to lower the frequency of PLPH.CONCLUSIONS:
Age, clinical diagnosis, and needle type were all determined to be predictive factors of PLPH.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Punción Espinal
/
Biomarcadores
/
Modelos Logísticos
/
Líquido Cefalorraquídeo
/
Entrevistas como Asunto
/
Estudios Retrospectivos
/
Factores de Riesgo
/
Estudios de Seguimiento
/
Diagnóstico
/
Cefalea Pospunción de la Duramadre
Tipo de estudio:
Estudio diagnóstico
/
Estudio de etiología
/
Estudio observacional
/
Estudio pronóstico
/
Investigación cualitativa
Idioma:
Inglés
Revista:
Dementia and Neurocognitive Disorders
Año:
2015
Tipo del documento:
Artículo
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