Molecular and Clinical Characterization of Hepatitis A Virus in Gwangju and Jeonnam Province / 대한소화기학회지
The Korean Journal of Gastroenterology
;
: 346-351, 2011.
Artículo
en Coreano
| WPRIM
| ID: wpr-150372
ABSTRACT
BACKGROUND/AIMS:
Dominant genotype of hepatitis A virus (HAV) in Korea had been known to be genotype 1A in 1990s. Recently, the epidemiologic change of HAV genotype was reported with an upsurge of acute hepatitis A in Korea. The aim of this study was to investigate the change of HAV genotypes and clinical characteristics in Gwangju and Jeonnam province.METHODS:
From November 2008 to October 2009, a total of 82 patients with acute hepatitis A were enrolled prospectively. HAV genotype was determined using reverse transcriptase polymerase chain reaction and sequencing of the PCR products of VP1/2A region of HAV.RESULTS:
HAV RNA was detected in 82% (67/82). The genotype IIIA (88%, 59 cases) was significantly more frequent than genotype IA (12%, 8 cases) (p< or =0.01). The subtypes of genotype IIIA were AJ299467 Norway (49%), HA-JNG04-09 Japan (27%), HS-14-12-00 Spain (22%) and H-122 Sweden (2%). The subtypes of IA were FH1 Japan (50%) and HA J04-3 Japan (50%). The substitutions of amino acid were more frequent in genotype IIIA than IA (p< or =0.01). There was no difference in the clinical characteristics between the patients with genotype IIIA and IA.CONCLUSIONS:
Genotype IIIA was a dominant genotype of recent HAV infection in Gwangju and Jeonnam province. This study provides valuable epidemiologic information of genetic distributions of HAV in Korea.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Idioma:
Coreano
Revista:
The Korean Journal of Gastroenterology
Año:
2011
Tipo del documento:
Artículo
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