Outcome after Partial Hepatectomy for Hepatocellular Carcinoma Combined with Liver Cirrhosis / 한국간담췌외과학회지

ABSTRACT

BACKGROUND/AIMS: Partial hepatectomy is considered as best treatment for selected HCC patients combined with liver cirrhosis. We conducted this study to assess the safety and effects of partial hepatectomy for HCC combined with liver cirrhosis and to identify the prognostic factors. METHODS: Retrospective analysis was performed for 115 HCC patients with liver cirrhosis who underwent hepatectomy in Korea Cancer Center Hospital from 1987 September to 2002 July. Median follow-up period was 30 months. RESULTS: In-hospital mortality rate was 0.87% (1/115 cases). 5-years overall and disease free survival rates were 59.3% and 44.75%, respectively. Fifty three patients developed recurrence and most common recurrent site was remnant liver (81.1%) and 3-year survival rate after recurrence was 33.4%. Independent prognostic factors for overall survival rate were TNM stage, multiplicity and venous invasion (p<0.05). CONCLUSION: Hepatectomy plays a significant role for HCC with compensated liver cirrhosis and is regarded as the effective treatment with acceptable mortality. However, recurrence rate is still high, so frequent follow-up study should be needed for early detection of recurrence amenable to effective treatment. For the high risk patients, further study should be followed to reduce the recurrence after hepatectomy, including surgical technique and adjuvant treatment.