Adenosine 5'-triphosphate induced NF-kappa B and intracellular calcium mobilization in cervical cancer cells / 대한산부인과학회지
Korean Journal of Obstetrics and Gynecology
;
: 2903-2909, 2005.
Artículo
en Inglés
| WPRIM
| ID: wpr-150617
ABSTRACT
OBJECTIVE:
To know the effect of adenosine 5'-triphosphate (ATP) on intracellular calcium level and cell proliferation in cervical cancer cells.METHODS:
Studydesign:
Four different human cervical cancer cell lines (Caski, C33A, HeLaS3 and SiHa) were used in this study. The change of intracellular calcium level, cell proliferation and the activity of proliferation- and calcium-related transcription factors by extracellular ATP were examined in these cell lines.RESULTS:
Extracellular ATP induced calcium mobilization, cell proliferation and the activation of NF-kappa B in all cell lines used.CONCLUSION:
These results suggest that calcium mobilization and NF-kappa B dependent signaling pathway play an important role in the cell proliferation by ATP in cervical cancer.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Factores de Transcripción
/
Adenosina
/
Línea Celular
/
Adenosina Trifosfato
/
Neoplasias del Cuello Uterino
/
Calcio
/
FN-kappa B
/
Proliferación Celular
Límite:
Humanos
Idioma:
Inglés
Revista:
Korean Journal of Obstetrics and Gynecology
Año:
2005
Tipo del documento:
Artículo
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