Immunohistochemical localization of galectin-3 in the granulomatous lesions of paratuberculosis-infected bovine intestine
Journal of Veterinary Science
; : 177-180, 2009.
Article
en En
| WPRIM
| ID: wpr-151429
Biblioteca responsable:
WPRO
ABSTRACT
The presence of galectin-3 was immunohistochemically quantified in bovine intestines infected with paratuberculosis (Johne's disease) to determine whether galectin-3 was involved in the formation of granulation tissue associated with the disease. Mycobacterium avium subsp. paratuberculosis infection was histochemically confirmed using Ziehl-Neelsen staining and molecularly diagnosed through rpoB DNA sequencing. Galectin-3 was detected in the majority of inflammatory cells, possibly macrophages, in the granulomatous lesions within affected tissues, including the ileum. These findings suggest that galectin-3 is associated with the formation of chronic granulation tissues in bovine paratuberculosis, probably through cell adhesion and anti-apoptosis mechanisms.
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Índice:
WPRIM
Asunto principal:
Paratuberculosis
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ARN Polimerasa II
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Inmunohistoquímica
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Enfermedades de los Bovinos
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Enfermedad Crónica
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Galectina 3
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Intestino Delgado
Límite:
Animals
Idioma:
En
Revista:
Journal of Veterinary Science
Año:
2009
Tipo del documento:
Article