Clinical characteristics of patients with acute hepatitis A in Gwangju-Chonnam province for recent 10 years / 대한내과학회지

ABSTRACT

BACKGROUND: The incidence of acute hepatitis A was reported to have increased recently. The purpose of this study was to investigate the epidemiological and clinical characteristics of cases of sporadic acute hepatitis A in Gwangju-Chonnnam area over the last 10 years. METHODS: The medical records of 73 cases with acute hepatitis A, which were diagnosed at the Chonnam National University Hospital from January 1996 to December 2005, were reviewed retrospectively for the epidemiological and clinical manifestations. RESULTS: Of the seventy three patients, there were forty males (54.8%). The mean age of the patients was 25 years and the peak incidence being in the 3rd decade (45.2%). The annual number of hepatitis A patients has increased. There were 16 patients (21.9%) from 1996 to 2000, and 57 patients (78.1%) from 2001 to 2005. There was no significant difference in the seasonal incidence (p=0.09). There were 7 cases (9.6%) in children less than 15 years of age and 66 adult cases (90.4%). Although the source of infection could not be identified in 40 patients (54.8%), it was found to be food in 31 patients (42.5%) and intimate contact in 2 patients (2.7%). Sixty five (89%) patients were hospitalized, and the average admission day was 14.5 days. All patients recovered without complications except for two patients who showed cholestatic hepatitis. CONCLUSIONS: The annual number of sporadic acute hepatitis A patients in Gwangju-Chonnam province has increased and most of patients were in their 3rd decade. Social concern for sporadic acute hepatitis A is needed in Gwangju-Chonnam area.