Relationship between 15-hydroxyprostaglandin dehydrogenase and gastric adenocarcinoma
Annals of Surgical Treatment and Research
; : 302-308, 2014.
Article
en En
| WPRIM
| ID: wpr-152271
Biblioteca responsable:
WPRO
ABSTRACT
PURPOSE: Prostaglandin E2 (PGE2) is a contributory carcinogen in gastric adenocarcinoma. 15-Hydroxyprostaglandin dehydrogenase (15-PGDH) catabolizes PGE2 by oxidizing its 15(s)-hydroxy group. The aim of this study was to investigate the expression of 15-PGDH in gastric adenocarcinoma tissue and the relationship between 15-PGDH expression and clinicopathologic features of gastric adenocarcinoma. METHODS: Ninety-nine patients who underwent surgical resection for gastric adenocarcinoma between January 2007 and December 2007 were enrolled and evaluated retrospectively. RESULTS: In 62 patients (62.6%), 15-PGDH expression was lower in gastric adenocarcinoma tissue than in nonneoplastic tissue. Regarding the relationship between 15-PGDH expression and clinicopathological features, 15-PGDH expression was significantly lower in tissues with poor differentiation (P = 0.002), advanced T stage (P = 0.0319), a higher number of lymph node metastases (P = 0.045), lymphatic invasion (P = 0.031), and vascular invasion (P = 0.036). CONCLUSION: 15-PGDH expression was associated with a subset of clinicopathologic features such as differentiation grade, T stage, lymphatic invasion, and vascular invasion.
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Índice:
WPRIM
Asunto principal:
Oxidorreductasas
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Neoplasias Gástricas
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Dinoprostona
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Adenocarcinoma
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Estudios Retrospectivos
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Ganglios Linfáticos
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Metástasis de la Neoplasia
Tipo de estudio:
Observational_studies
Límite:
Humans
Idioma:
En
Revista:
Annals of Surgical Treatment and Research
Año:
2014
Tipo del documento:
Article