Klotho and the Aging Process
The Korean Journal of Internal Medicine
;
: 113-122, 2011.
Artículo
en Inglés
| WPRIM
| ID: wpr-152504
ABSTRACT
The klotho gene was originally identified as a putative age-suppressing gene in mice that extends life span when overexpressed. It induces complex phenotypes resembling human premature aging syndromes when disrupted. The gene was named after a Greek goddess Klotho who spun the thread of life. Since then, various functional aspects of the klotho gene have been investigated, leading to the identification of multiple novel endocrine axes that regulate various metabolic processes and an unexpected link between mineral metabolism and aging. The purposes of this review were to overview recent progress on Klotho research and to discuss a novel aging mechanism.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Fenotipo
/
Fosfatos
/
Envejecimiento
/
Transducción de Señal
/
Enfermedad Crónica
/
Fósforo Dietético
/
Factores de Crecimiento de Fibroblastos
/
Glucuronidasa
/
Homeostasis
/
Enfermedades Renales
Tipo de estudio:
Estudio pronóstico
Límite:
Animales
/
Humanos
Idioma:
Inglés
Revista:
The Korean Journal of Internal Medicine
Año:
2011
Tipo del documento:
Artículo
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