A Case of Acute Promyelocytic Leukemia with a De novo t(11;19) Chromosomal Translocation / 대한내과학회지
Korean Journal of Medicine
;
: S268-S272, 2011.
Artículo
en Coreano
| WPRIM
| ID: wpr-152515
ABSTRACT
Acute promyelocytic leukemia (APL), which is usually defined by the morphological features of the leukemic cells, is characterized by the t(15;17) (q22;q21) chromosomal translocation and disseminated intravascular coagulation. This specific translocation results in a new fusion transcript between the promyelocytic leukemia (PML) gene and the retinoic acid receptor-alpha (RARalpha) gene. Although the presence of this fusion gene can predict a favorable clinical response to all-trans-retinoic-acid (ATRA) treatment, APL with chromosomal translocations other than t(15;17) (q22;q21) is extremely rare and is associated with a poor prognosis. We experienced a case of APL with de novo t(11;19).
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Pronóstico
/
Translocación Genética
/
Tretinoina
/
Leucemia Promielocítica Aguda
/
Leucemia
/
Coagulación Intravascular Diseminada
/
Patología Molecular
Tipo de estudio:
Estudio diagnóstico
/
Estudio pronóstico
Idioma:
Coreano
Revista:
Korean Journal of Medicine
Año:
2011
Tipo del documento:
Artículo
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