Relationship between the hepatic venous pressure gradient and first variceal hemorrhage in patients with cirrhosis: a multicenter retrospective study in Korea
Clinical and Molecular Hepatology
;
: 391-396, 2012.
Artículo
en Inglés
| WPRIM
| ID: wpr-15271
ABSTRACT
BACKGROUND/AIMS:
Variceal hemorrhage is one of the major complications of cirrhosis and is associated with significant mortality and morbidity. The development of gastroesophageal varices and variceal hemorrhage is the most direct consequence of portal hypertension. Correlations between the hepatic venous pressure gradient (HVPG) and first variceal hemorrhage were examined.METHODS:
Patients with cirrhosis who underwent HVPG measurement between July 2009 and September 2010 were enrolled (n=535). All patients underwent esophagogastroduodenoscopy to enable the evaluation of gastroesophageal varices.RESULTS:
The HVPG for all patients was 16.46+/-7.05 mmHg (mean+/-SD), and was significantly higher among those with first variceal hemorrhage than in those without it. The HVPG was significantly correlated with both Child-Turcotte-Pugh (r=0.488, P<0.001) and Model for End-stage Liver Disease (r=0.478, P<0.001) scores. An HVPG value of 11 mmHg was predictive of first variceal hemorrhage with a sensitivity of 92.4% and a specificity of 27.7%.CONCLUSIONS:
The HVPG was higher in patients with first variceal hemorrhage than in those without it.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Presión Venosa
/
Índice de Severidad de la Enfermedad
/
Várices Esofágicas y Gástricas
/
Estudios Retrospectivos
/
República de Corea
/
Catéteres
/
Hemorragia Gastrointestinal
/
Cirrosis Hepática
Tipo de estudio:
Estudio observacional
/
Estudio pronóstico
Límite:
Adulto
/
Femenino
/
Humanos
/
Masculino
País/Región como asunto:
Asia
Idioma:
Inglés
Revista:
Clinical and Molecular Hepatology
Año:
2012
Tipo del documento:
Artículo
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