The Relationship between the SNAP-25 Polymorphism and Omission Errors in Korean Children with Attention Deficit Hyperactivity Disorder
Clinical Psychopharmacology and Neuroscience
;
: 222-228, 2017.
Artículo
en Inglés
| WPRIM
| ID: wpr-152986
ABSTRACT
OBJECTIVE:
This study aimed to investigate the association between the synaptosomal-associated protein 25 kDa (SNAP-25) genotype and performance on the continuous performance test (CPT) in Korean children with attention-deficit/hyperactivity disorder (ADHD).METHODS:
Eighty-seven children with ADHD (mean age, 9.23±1.99 years) participated in this study. Omission errors, commission errors, reaction time, and reaction time variability on the CPT were analyzed. The single-nucleotide polymorphism (SNP) rs3746544 (1065 T>G) of SNAP-25 was genotyped to examine the association with CPT performance.RESULTS:
We found significantly more omission errors on the CPT among children with the TT genotype of SNAP-25 (t=2.56, p=0.012) after correcting for multiple testing.CONCLUSION:
Our results suggest the possible involvement of the SNAP-25 1065 T>G polymorphism in the inattention phenotype in children with ADHD. Further studies with more refined neuropsychological measures and much larger sample sizes are needed to confirm our findings.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Fenotipo
/
Tiempo de Reacción
/
Trastorno por Déficit de Atención con Hiperactividad
/
Tamaño de la Muestra
/
Proteína 25 Asociada a Sinaptosomas
/
Genotipo
Límite:
Niño
/
Humanos
Idioma:
Inglés
Revista:
Clinical Psychopharmacology and Neuroscience
Año:
2017
Tipo del documento:
Artículo
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