Induction of thermogenic adipocytes: molecular targets and thermogenic small molecules
Experimental & Molecular Medicine
;
: e353-2017.
Artículo
en Inglés
| WPRIM
| ID: wpr-153369
ABSTRACT
Adipose tissue is a central metabolic organ that controls energy homeostasis of the whole body. White adipose tissue (WAT) stores excess energy in the form of triglycerides, whereas brown adipose tissue (BAT) dissipates energy in the form of heat through mitochondrial uncoupling protein 1 (Ucp1). A newly identified adipose tissue called ‘beige fat’ (BAT-like) is produced through a process called WAT browning. This tissue mainly resides in WAT depots and displays intermediate characteristics of both WAT and BAT. Since the recent discovery of BAT in the human body, along with the identification of molecular targets for BAT activation, stimulating energy expenditure has been considered as a great strategy to treat human obesity and metabolic diseases. Here we summarize recent findings regarding molecular targets and thermogenic small molecules that can stimulate BAT and increase energy expenditure, with an emphasis on possible therapeutic applications in humans.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Triglicéridos
/
Tejido Adiposo Pardo
/
Tejido Adiposo
/
Adipocitos
/
Cuerpo Humano
/
Metabolismo Energético
/
Tejido Adiposo Blanco
/
Calor
/
Homeostasis
/
Enfermedades Metabólicas
Tipo de estudio:
Estudio pronóstico
Límite:
Humanos
Idioma:
Inglés
Revista:
Experimental & Molecular Medicine
Año:
2017
Tipo del documento:
Artículo
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