The molecular mechanism for nuclear transport and its application / 대한해부학회지
Anatomy & Cell Biology
;
: 77-85, 2017.
Artículo
en Inglés
| WPRIM
| ID: wpr-153457
ABSTRACT
Transportation between the cytoplasm and the nucleoplasm is critical for many physiological and pathophysiological processes including gene expression, signal transduction, and oncogenesis. So, the molecular mechanism for the transportation needs to be studied not only to understand cell physiological processes but also to develop new diagnostic and therapeutic targets. Recent progress in the research of the nuclear transportation (import and export) via nuclear pore complex and four important factors affecting nuclear transport (nucleoporins, Ran, karyopherins, and nuclear localization signals/nuclear export signals) will be discussed. Moreover, the clinical significance of nuclear transport and its application will be reviewed. This review will provide some critical insight for the molecular design of therapeutics which need to be targeted inside the nucleus.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Transportes
/
Transducción de Señal
/
Expresión Génica
/
Fenómenos Fisiológicos Celulares
/
Señales de Localización Nuclear
/
Poro Nuclear
/
Transporte Activo de Núcleo Celular
/
Citoplasma
/
Carioferinas
/
Proteínas de Complejo Poro Nuclear
Idioma:
Inglés
Revista:
Anatomy & Cell Biology
Año:
2017
Tipo del documento:
Artículo
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