Gender-specific Association between Polymorphism of Vascular Endothelial Growth Factor (VEGF 936C>T) Gene and Patients with Stomach Cancer
Yonsei Medical Journal
;
: 783-791, 2008.
Artículo
en Inglés
| WPRIM
| ID: wpr-153698
ABSTRACT
PURPOSE:
Angiogenesis plays an important role in the growth, progression, and metastasis of tumors. Vascular endothelial growth factor (VEGF) overexpression has been associated with advanced stage and poor survival in several cancers. We investigated the present case-control study to determine whether there is an association between the VEGF 936C>T polymorphism and stomach cancer. PATIENTS ANDMETHODS:
The association of functional single nucleotide polymorphisms (SNPs) of the VEGF gene with stomach cancer development was evaluated in a case-control study of 154 Korean stomach cancer patients. Genotypes were determined by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) analysis.RESULTS:
Our results revealed significant association of T allele-bearing genotypes with increased risk for stomach cancer development. Genotype frequencies of the VEGF 936C>T polymorphisms were significantly different between patient and control groups (CT, AOR 2.007, 95% CI 1.277-3.156, TT, AOR 4.790, 95% CI 1.174-19.539, CT+TT, AOR 2.147, 95% CI 1.382-3.337). When stratified by gender and age, genotype frequencies were significantly different for stomach cancer in women and in patients younger than 55 years (in women, CT, OR 3.049, 95% CI 1.568-5.930, CT+TT, OR 3.132, 95% CI 1.638-5.990; in T polymorphism is a susceptibility factor for stomach cancer, at least in Korean. These observations, however, require further confirmation by a larger multi-ethnic study.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Polimorfismo Genético
/
Neoplasias Gástricas
/
Estudios de Casos y Controles
/
Factores Sexuales
/
Factor A de Crecimiento Endotelial Vascular
/
Genotipo
Tipo de estudio:
Estudio observacional
/
Factores de riesgo
Límite:
Adulto
/
Anciano
/
Aged80
/
Femenino
/
Humanos
/
Masculino
Idioma:
Inglés
Revista:
Yonsei Medical Journal
Año:
2008
Tipo del documento:
Artículo
Similares
MEDLINE
...
LILACS
LIS