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Leptomeningeal Carcinomatosis in Solid Tumors; Clinical Manifestation and Treatment / 대한암학회지
Journal of the Korean Cancer Association ; : 34-40, 2001.
Artículo en Coreano | WPRIM | ID: wpr-153903
ABSTRACT

PURPOSE:

Leptomeningeal carcinomatosis occurs in about 5% of patients with solid tumor and is being diagnosed with increasing frequency as patients live longer and as neuro-imaging studies improve. In general, the most commom cancers that involved the leptomeninges are breast cancer, lung cancer, and malignant melanoma. MATERIALS AND

METHODS:

We investigated 25 patients presented with multiple neurologic symptoms and signs who were diagnosed with leptomeningeal carcinomatosis at the Yonsei Cancer Center from January 1990 to December 1999.

RESULTS:

The primary disease of leptomeningeal carcinomatosis were stomach cancer (10 cases), breast cancer (7 cases), lung cancer (5 cases), unknown primary cancer (2 cases) and common bile duct cancer (1 case). All patients were presented with multiple neurologic symptoms and signs involving the central nervous system (CNS), cranial nerve or spinal nerves. Twenty-one of twenty- five patients were treated with intrathecal chemotherapy, radiotherapy, or combination therapy. Fourteen of them (66.7%) experienced improvement or stabilization of neurologic symptom and sign. The median survival was 122 days (10-2190).

CONCLUSION:

In conclusion, although early diagnosis and active treatment of leptomeningeal carcinomatosis may improve the quality of life in selected patients, the median survival was relatively short. Therefore, new diagnostic and therapeutic strategy for leptomeningeal carcinomatosis were needed.
Asunto(s)

Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Calidad de Vida / Radioterapia / Nervios Espinales / Neoplasias Gástricas / Neoplasias de la Mama / Sistema Nervioso Central / Conducto Colédoco / Nervios Craneales / Diagnóstico Precoz / Quimioterapia Tipo de estudio: Estudio diagnóstico / Estudio de tamizaje Límite: Humanos Idioma: Coreano Revista: Journal of the Korean Cancer Association Año: 2001 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Calidad de Vida / Radioterapia / Nervios Espinales / Neoplasias Gástricas / Neoplasias de la Mama / Sistema Nervioso Central / Conducto Colédoco / Nervios Craneales / Diagnóstico Precoz / Quimioterapia Tipo de estudio: Estudio diagnóstico / Estudio de tamizaje Límite: Humanos Idioma: Coreano Revista: Journal of the Korean Cancer Association Año: 2001 Tipo del documento: Artículo