Changes of Bone Mineral Densities in Children with Idiopathic Hypercalciuria / 대한신장학회지
Korean Journal of Nephrology
; : 684-690, 2007.
Article
en Ko
| WPRIM
| ID: wpr-15400
Biblioteca responsable:
WPRO
ABSTRACT
PURPOSE: Idiopathic hypercalciuria is a common clinical disorder in children with hematuria or nephrolithiasis. Recently, it has been reported that idiopathic hypercalciuria may disturb the metabolism of bone and induce its loss. We measured the biochemical markers of bone metabolism and bone mineral densities (BMD) by dual energy X-ray absorptiometry (DEXA) in children with idiopathic hypercalciuria to elucidate the prevalence and clinical significance of osteopenia. METHODS: From 1997 to 2005, 52 children with idiopathic hypercalciuria were included in this study. The biochemical markers of bone metabolism were measured in all 52 patients. BMD was measured in 21 patients initially and additional 6 patients during the follow-up. RESULTS: Mean age of patients was 6 years 7 months, and the male to female ratio was 1.26:1. BMD Z-scores were less than -1 in 10 of initial 21 patients (osteopenia), and -2.5 in 2 of 10 osteopenic patients (osteoporosis). There was a negative correlation between BMD Z-score and the level of osteocalcin. However, there were no significant differences in BMD Z-scores and other biochemical markers of bone metabolism among groups divided by sex, the type of idiopathic hypercalciuria, and the presence of urinary stone. CONCLUSION: Idiopathic hypercalciuria can be not only the cause of hematuria, but also of osteopenia in children. We suggest that the measurement of BMD in children with idiopathic hypercalciuria should be performed routinely with regular follow-up.
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Índice:
WPRIM
Asunto principal:
Enfermedades Óseas Metabólicas
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Biomarcadores
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Cálculos Urinarios
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Absorciometría de Fotón
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Densidad Ósea
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Osteocalcina
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Prevalencia
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Estudios de Seguimiento
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Nefrolitiasis
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Hipercalciuria
Tipo de estudio:
Observational_studies
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Prevalence_studies
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Prognostic_studies
Límite:
Child
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Female
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Humans
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Male
Idioma:
Ko
Revista:
Korean Journal of Nephrology
Año:
2007
Tipo del documento:
Article