Rapid detection of aneuploidy in uncultured fetal cord blood cells by FISH ( Fluorescence In Situ Hybridization ) / 대한산부인과학회잡지
Korean Journal of Obstetrics and Gynecology
; : 386-390, 2000.
Article
en Ko
| WPRIM
| ID: wpr-154482
Biblioteca responsable:
WPRO
ABSTRACT
OBJECTIVE: To determine the fetal aneuploidy in fetal blood cells from cordocentesis. METHODS: We analyzed their karyotype and performed fluorescence in situ hybridization(FISH) for chromosome 18, 21, X, and Y in 14 cases of fetal blood cells from cordocentesis at Department of Obstetrics & Gynecology, College of Medicine, Seoul National University and Hamchoon Women's Clinic. RESULTS: In all cases we obtained the consistent results in both methods and were able to rapidly detect aneuploidy in uncultured fetal blood cells using FISH before karyotyping with culture for 48 hr. The averages for accuracy of FISH were from 84.6 % to 93.9%. CONCLUSION: In this study we suggest that the rapid detection in uncultured fetal blood using FISH is possible and that this diagnostic method will be clinically useful when rapid result would be demanded.
Palabras clave
Texto completo:
1
Índice:
WPRIM
Asunto principal:
Cromosomas Humanos Par 18
/
Hibridación in Situ
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Cordocentesis
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Sangre Fetal
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Cariotipo
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Seúl
/
Fluorescencia
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Ginecología
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Cariotipificación
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Aneuploidia
Tipo de estudio:
Diagnostic_studies
País/Región como asunto:
Asia
Idioma:
Ko
Revista:
Korean Journal of Obstetrics and Gynecology
Año:
2000
Tipo del documento:
Article