Your browser doesn't support javascript.
loading
Sulindac Prevents Esophageal Adenocarcinomas Induced by Gastroduodenal Reflux in Rats
Yonsei Medical Journal ; : 1020-1027, 2007.
Artículo en Inglés | WPRIM | ID: wpr-154647
ABSTRACT

PURPOSE:

It is known that cyclooxygenase (COX)-2 expression is increased in Barrett's esophagus and esophageal adenocarcinomas. We studied COX-2 expression and the effect sulindac has on the genesis of Barrett's esophagus and adenocarcinoma in rats undergoing esophagogastroduodenal anastomosis (EGDA). MATERIALS AND

METHODS:

Fifty-one rats were divided into a control group (n=27), a 500ppm sulindac-treated group (n=15) and 1000 ppm sulindac-treated group (n=9). Randomly selected rats were killed by diethyl ether inhalation at 20 and 40 weeks after surgery.

RESULTS:

At 40 weeks, rats treated with 1000 ppm sulindac showed narrower esophageal diameter and milder inflammation than the control rats. At 40 weeks, the incidence of Barrett's esophagus was similar between control and sulindac-treated groups, but the incidence of adenocarcinoma was significantly lower in the 1000ppm sulindac-treated group than either the control or 500 ppm sulindac-treated groups. COX-2 was significantly increased in the lower esophagus of control rats killed at 40 weeks. Cyclin D1 expression was negligible in the sulindac- treated group compared with the control group.

CONCLUSION:

We suggest that the chemopreventive effect of sulindac is related to decreased COX-2 and cyclin D1 expression, which may be influenced by reduced inflammation.
Asunto(s)

Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Esófago de Barrett / Neoplasias Esofágicas / Inmunohistoquímica / Adenocarcinoma / Sulindac / Western Blotting / Ratas Sprague-Dawley / Antígeno Nuclear de Célula en Proliferación / Ciclina D1 / Reflujo Duodenogástrico Límite: Animales Idioma: Inglés Revista: Yonsei Medical Journal Año: 2007 Tipo del documento: Artículo

Similares

MEDLINE

...
LILACS

LIS

Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Esófago de Barrett / Neoplasias Esofágicas / Inmunohistoquímica / Adenocarcinoma / Sulindac / Western Blotting / Ratas Sprague-Dawley / Antígeno Nuclear de Célula en Proliferación / Ciclina D1 / Reflujo Duodenogástrico Límite: Animales Idioma: Inglés Revista: Yonsei Medical Journal Año: 2007 Tipo del documento: Artículo