Comparison of clinical and laboratory characteristics in children with type 1 diabetes according to pancreatic autoantibodies / 소아과
Korean Journal of Pediatrics
;
: 414-419, 2010.
Artículo
en Coreano
| WPRIM
| ID: wpr-155213
ABSTRACT
PURPOSE:
The purpose of this study was to determine whether there is any difference in the clinical and laboratory characteristics of patients with autoantibody-positive and patients with autoantibody-negative type 1 diabetes at initial presentation.METHODS:
We analyzed 96 patients under 18 years of age with newly diagnosed type 1 diabetes. One or both of the pancreatic autoantibodies-glutamic acid decarboxylase autoantibodies (GADA) and insulin autoantibody (IAA)-were measured in all patients, and we reviewed clinical and laboratory characteristics according to the presence of these autoantibodies.RESULTS:
GADA was examined in 48 of 87 patients, and 55.2% of patients were positive. IAA was checked in 88 patients, and 39.8% were positive. Both GADA and IAA were measured in 83 patients, and 22.8% had both antibodies. The patients who had one or both autoantibodies (autoantibody-positive group) were younger than those not having any autoantibody (autoantibody-negative group). The autoantibody-positive group had lower BMI, corrected sodium level, and serum effective osmolarity, compared to the autoantibody-negative group (P<0.05). Similar differences were found between the GADA-positive and GADA-negative groups. However, there were no significant differences between the IAA-positive and IAA-negative groups.CONCLUSION:
The prevalence of pancreatic autoantibodies was significantly higher in the under-6 years age group than in the other age groups. These findings suggest that measurement of autoantibodies at the initial diagnosis of diabetes is very useful for detecting immune-mediated type 1 diabetes and providing intensive insulin therapy, especially in younger children.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Concentración Osmolar
/
Autoanticuerpos
/
Sodio
/
Prevalencia
/
Insulina
/
Anticuerpos
Tipo de estudio:
Estudio de prevalencia
Límite:
Niño
/
Humanos
Idioma:
Coreano
Revista:
Korean Journal of Pediatrics
Año:
2010
Tipo del documento:
Artículo
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