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The Bacterial Protein Azurin Enhances Sensitivity of Oral Squamous Carcinoma Cells to Anticancer Drugs
Yonsei Medical Journal ; : 773-778, 2011.
Artículo en Inglés | WPRIM | ID: wpr-155384
ABSTRACT

PURPOSE:

Surgical therapy is the primary treatment for oral cancer, but it can cause facial distortion. Therefore, if anticancer drugs are effective against oral cancer, they may be used preferentially. However, oral squamous carcinoma cells (OSCCs) are resistant to these drugs, so finding a way to enhance the sensitivity of these cells to anticancer drugs is important. The bacterial protein azurin is known to selectively enter cancer cells and induce apoptosis. In this study, we show the anticancer effect of azurin in OSCC. MATERIALS AND

METHODS:

OSCC cell line (YD-9) was subjected to azurin treatment. Cell viability, morphology and protein expression levels were monitored after treatment of azurin. Cells were also subjected to combination treatment of azurin with either 5-fluorouracil or etopside.

RESULTS:

Azurin-treated cells showed decreased cell viability accompanied by apoptotic phenotypes including morphological change, DNA breakage, and increases in p53 and cyclin B1 protein levels. Combination treatment of azurin with other anti-tumor agents caused an increase in sensitivity to anticancer drugs in azurin-treated YD-9 cells.

CONCLUSION:

Azurin has a strong synergistic anticancer effect on oral cancer cells when it is used along with anticancer drugs.
Asunto(s)

Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Azurina / Neoplasias de la Boca / Carcinoma de Células Escamosas / Proteína p53 Supresora de Tumor / Apoptosis / Línea Celular Tumoral / Sinergismo Farmacológico / Etopósido / Ciclina B1 / Fluorouracilo Tipo de estudio: Estudio diagnóstico Límite: Humanos Idioma: Inglés Revista: Yonsei Medical Journal Año: 2011 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Azurina / Neoplasias de la Boca / Carcinoma de Células Escamosas / Proteína p53 Supresora de Tumor / Apoptosis / Línea Celular Tumoral / Sinergismo Farmacológico / Etopósido / Ciclina B1 / Fluorouracilo Tipo de estudio: Estudio diagnóstico Límite: Humanos Idioma: Inglés Revista: Yonsei Medical Journal Año: 2011 Tipo del documento: Artículo