A Long Term Results of External Beam Radiation Therapy in Hemophilic Arthropathy of the Ankle in Children
Journal of Korean Medical Science
; : 1742-1747, 2010.
Article
en En
| WPRIM
| ID: wpr-15540
Biblioteca responsable:
WPRO
ABSTRACT
Bleeding into joint space is critical to develop hemophilic arthropathy. To reduce the frequency of bleeding in the ankle joint of children with hemophilic arthropathy, low dose external beam irradiation was performed for 37 patients. Among them, 35 patients followed-up for longer than 1 yr (median 87 months) were enrolled for analysis. The average number of bleedings per month was 3.6 during one year prior to radiation therapy. After radiation therapy, it was decreased to 2.1 during the first year, after then it was maintained in the range of 1.0 to 1.5 until the tenth year. The bleeding frequency was reduced to 42% at the first year and it was maintained in the range of 58% to 73% from the second to the tenth year. Especially the patients who had 3 or more bleedings per month, and who had MRI score more than 3 showed significant decreases. During the follow-up period, growth disturbances and secondary malignancies were not found. External beam radiotherapy can be considered for the hemophilic patients with surgical or isotope therapies are not amenable.
Palabras clave
Texto completo:
1
Índice:
WPRIM
Asunto principal:
Pronóstico
/
Hemartrosis
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Hemofilia A
/
Articulación del Tobillo
Tipo de estudio:
Prognostic_studies
Límite:
Adolescent
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Child
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Child, preschool
/
Humans
/
Male
Idioma:
En
Revista:
Journal of Korean Medical Science
Año:
2010
Tipo del documento:
Article