A Case of Myeloid Neoplasm with a PDGFRB Rearrangement and Eosinophilia / 대한내과학회지
Korean Journal of Medicine
;
: 79-83, 2017.
Artículo
en Coreano
| WPRIM
| ID: wpr-155824
ABSTRACT
Myeloid neoplasia with eosinophilia and platelet-derived growth factor receptor beta (PDGFRB) rearrangements is an uncommon Philadelphia-negative myeloproliferative neoplasm. Their most common morphological diagnosis is chronic myelomonocytic leukemia with eosinophilia, which is associated with t(5;12)(q33;p13) and results in the formation of the ETV6-PDGFRB fusion gene. Here, we report a 49-year-old man with a myeloid neoplasm with a PDGFRB rearrangement, who was incidentally diagnosed with hyperleukocytosis and eosinophilia during a health screening. A chromosome analysis of a bone marrow sample revealed 46, XY, t(5;12)(q33;p13), and fluorescence in situ hybridization analysis revealed the PDGFRB gene rearrangement. The patient was treated with imatinib and subsequently achieved complete hematological and molecular remission.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Médula Ósea
/
Reordenamiento Génico
/
Leucemia Mielomonocítica Crónica
/
Tamizaje Masivo
/
Receptores del Factor de Crecimiento Derivado de Plaquetas
/
Hibridación in Situ
/
Receptor beta de Factor de Crecimiento Derivado de Plaquetas
/
Diagnóstico
/
Eosinofilia
/
Fluorescencia
Tipo de estudio:
Estudio diagnóstico
/
Estudio pronóstico
/
Estudio de tamizaje
Límite:
Humanos
Idioma:
Coreano
Revista:
Korean Journal of Medicine
Año:
2017
Tipo del documento:
Artículo
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