The Frequencies of HLA Alleles in Bipolar Disorder / 신경정신의학

ABSTRACT

OBJECTIVES: To evaluate the potential of HLA as a candidate gene for the genetic marker of bipolar disorder, we carried out the association study between allelic frequency of HLA and bipolar disorder. METHODS: HLA class I and class II allelic frequencies were assessed in 87 Korean bipolar disorder patients and were compared with the data from 206 normal controls. HLA class I typing was performed with microlymphocytotoxicity method and HLA class II(DQB1 and DRB1) genotyping with reverse dot hybridization. The allelic frequencies were analyzed using x2 test with two-tailed Fisher's exact test. RESULTS: Bipolar disorder patients showed increased allelic frequencies of HLA-A29 and B54 and decreased allelic frequencies of HLA-B51 and DRB1*02 compared to normal controls. CONCLUSION: These results suggest the possibility of association between HLA gene and bipolar disorder. To clarify the genetic influences of HLA on bipolar disorder, further systematic studies should be conducted.