RET Fusion Genes in Korean Non-Small Cell Lung Cancer
Journal of Korean Medical Science
;
: 1555-1558, 2013.
Artículo
en Inglés
| WPRIM
| ID: wpr-155940
ABSTRACT
Recently, rearranged during transfection (RET) fusions have been identified in approximately 1% of non-small cell lung cancer (NSCLC). To know the prevalence of RET fusion genes in Korean NSCLCs, we examined the RET fusion genes in 156 surgically resected NSCLCs using a reverse transcriptase polymerase chain reaction. Two KIF5B-RET fusions and one CCDC6-RET fusion were identified. All three patients were females and never smokers with adenocarcinomas. RET fusion genes were mutually exclusive from EGFR, KRAS mutations and EML4-ALK fusion. RET fusion genes occur 1.9% (3 of 156) of surgically treated NSCLC patients in Koreans.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Proteínas de Fusión Oncogénica
/
Cinesinas
/
Análisis de Secuencia de ADN
/
Carcinoma de Pulmón de Células no Pequeñas
/
Proteínas del Citoesqueleto
/
Pueblo Asiatico
/
Proteínas Proto-Oncogénicas c-ret
/
República de Corea
/
Neoplasias Pulmonares
Límite:
Femenino
/
Humanos
País/Región como asunto:
Asia
Idioma:
Inglés
Revista:
Journal of Korean Medical Science
Año:
2013
Tipo del documento:
Artículo
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