Hydrogen Peroxide Upregulates TNF-Related Apoptosis-Inducing Ligand (TRAIL) Expression in Human Astroglial Cells, and Augments Apoptosis of T Cells
Yonsei Medical Journal
;
: 551-557, 2006.
Artículo
en Inglés
| WPRIM
| ID: wpr-156133
ABSTRACT
The brain is particularly vulnerable to oxygen free radicals, and these radicals have been implicated in the pathology of several neurological disorders. In this study, the modulation of TNF-related apoptosis-inducing ligand (TRAIL) expression by oxidative stress was shown in LN215 cells, an astroglioma cell line. Hydrogen peroxide (H2O2) treatment increased TRAIL expression in LN215 cells and H2O2-induced TRAIL augmented apoptosis in Peer cells, a cell line sensitive to TRAIL- mediated cell death. Our findings suggest that the upregulation of TRAIL in astroglial cells may abrogate immune cell effector functions.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Ribonucleasas
/
Linfocitos T
/
Regulación Neoplásica de la Expresión Génica
/
Regulación hacia Arriba
/
Astrocitos
/
Ciclosporina
/
Apoptosis
/
Estrés Oxidativo
/
Línea Celular Tumoral
/
Alergia e Inmunología
Límite:
Humanos
Idioma:
Inglés
Revista:
Yonsei Medical Journal
Año:
2006
Tipo del documento:
Artículo
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