Screening of the Presence of Hepatitis B and C Virus Infections in Terminally Failing Human Hearts
Korean Circulation Journal
;
: 83-93, 2001.
Artículo
en Coreano
| WPRIM
| ID: wpr-156477
ABSTRACT
In order to evaluate the prevalence of hepatitis B virus (HBV) and hepatitis C virus (HCV) infections in terminally failing hearts, we screened the explanted hearts of transplantation recipients for the presence of HBV DNA and HCV RNA. DNA and RNA extractions were taken from explanted failing hearts (N=7) and normal hearts (N=). Polymerase chain reaction (PCR) and in situ PCR of HBV or reverse transcription-polymerase chain reaction (RT-PCR) and in situ RT-PCR of HCV were performed. The positivity of HBV in failing hearts was 63% (17/27) and it was 50% (3/6) in normal hearts in PCR. There was no significant difference in the positivity of HBV DNA between failing and normal hearts. The positivity of HCV in failing hearts was 18.5% (5/27) and it was 16.7% (1/6) in normal hearts in nested RT-PCR. There was no significant difference in the positivity of HCV RNA between failing and normal hearts. HCV was very rarely observed in explanted terminally failing hearts and HBV was frequently found in both explanted failing hearts and normal hearts. We concluded that these viruses have little direct causal relationship with the development of heart failure.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
ADN
/
ARN
/
Virus de la Hepatitis B
/
Tamizaje Masivo
/
Reacción en Cadena de la Polimerasa
/
Prevalencia
/
Hepacivirus
/
Corazón
/
Insuficiencia Cardíaca
/
Hepatitis
Tipo de estudio:
Estudio diagnóstico
/
Estudio de prevalencia
/
Estudio de tamizaje
Límite:
Humanos
Idioma:
Coreano
Revista:
Korean Circulation Journal
Año:
2001
Tipo del documento:
Artículo
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