Application of Iron Related Magnetic Resonance Imaging in the Neurological Disorders / 대한임상신경생리학회지
Korean Journal of Clinical Neurophysiology
;
: 1-7, 2014.
Artículo
en Coreano
| WPRIM
| ID: wpr-156824
ABSTRACT
Iron is an important element for brain oxygen transport, myelination, DNA synthesis and neurotransmission. However, excessive iron can generate reactive oxygen species and contribute neurotoxicity. Although brain iron deposition is the natural process with normal aging, excessive iron accumulation is also observed in various neurological disorders such as neurodegeneration with brain iron accumulation, Parkinson's disease, Alzheimer's disease, multiple sclerosis, Friedreich ataxia, and others. Magnetic resonance image (MRI) is a useful method for detecting iron deposits in the brain. It can be a powerful tool for diagnosis and monitoring, while furthering our understanding of the role of iron in the pathophysiology of a disease. In this review, we will introduce the mechanism of iron toxicity and the basics of several iron-related MRI techniques. Also, we will summarize the previous results concerning the clinical application of such MR imagings in various neurological disorders.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Oxígeno
/
Enfermedad de Parkinson
/
Encéfalo
/
Envejecimiento
/
ADN
/
Ataxia de Friedreich
/
Imagen por Resonancia Magnética
/
Especies Reactivas de Oxígeno
/
Transmisión Sináptica
/
Enfermedades Neurodegenerativas
Tipo de estudio:
Estudio diagnóstico
Idioma:
Coreano
Revista:
Korean Journal of Clinical Neurophysiology
Año:
2014
Tipo del documento:
Artículo
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