Caveolin-1 upregulation in senescent neurons alters amyloid precursor protein processing
Experimental & Molecular Medicine
;
: 126-133, 2006.
Artículo
en Inglés
| WPRIM
| ID: wpr-15699
ABSTRACT
Lipid rafts provide a platform for regulating cellular functions and participate in the pathogenesis of several diseases. However, the role of caveolin-1 in this process has not been elucidated definitely in neuron. Thus, this study was performed to examine whether caveolin-1 can regulate amyloid precursor protein (APP) processing in neuronal cells and to identify the molecular mechanisms involved in this regulation. Caveolin-1 is up-regulated in all parts of old rat brain, namely hippocampus, cerebral cortex and in elderly human cerebral cortex. Moreover, detergent-insoluble glycolipid (DIG) fractions indicated that caveolin-1 was co-localized with APP in caveolae-like structures. In DIG fractions, bAPP secretion was up-regulated by caveolin-1 over-expression, which was modulated via protein kinase C (PKC) in neuroblastoma cells. From these results we conclude that caveolin-1 is selectively expressed in senescent neurons and that it induces the processing of APP by beta-secretase via PKC downregulation.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Encéfalo
/
Proteína Quinasa C
/
Envejecimiento
/
Microscopía Electrónica
/
Regulación hacia Arriba
/
Péptidos beta-Amiloides
/
Precursor de Proteína beta-Amiloide
/
Receptores de Superficie Celular
/
Caveolas
/
Caveolina 1
Límite:
Aged80
/
Animales
/
Humanos
Idioma:
Inglés
Revista:
Experimental & Molecular Medicine
Año:
2006
Tipo del documento:
Artículo
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