N-Acetylcysteine Improves Pancreatic Microcirculation and Alleviates the Severity of Acute Necrotizing Pancreatitis
Gut and Liver
;
: 357-362, 2013.
Artículo
en Inglés
| WPRIM
| ID: wpr-158228
ABSTRACT
BACKGROUND/AIMS:
To investigate the beneficial effect of N-Acetylcysteine (NAC) on pancreatic microvascular perfusion in acute necrotizing pancreatitis (ANP).METHODS:
Fifty-four rats were divided into a control group, an ANP group and an NAC-treated group. The ANP model was established by a retrograde injection of 3% sodium taurocholate into the pancreatic duct. The NAC-treated group received an intravenous infusion of NAC just 2 hours before and 30 minutes after the induction of ANP. The pancreatic microvascular perfusion was measured with laser Doppler flowmetry and pancreatic samples were collected for histological examination.RESULTS:
The microvascular perfusion in the NAC-treated group decreased slightly and exhibited a significant increase compared to the ANP group (p<0.01). A pathological examination revealed that edema and inflammatory infiltration decreased, and the hemorrhaging and necrosis of the pancreas were significantly reduced.CONCLUSIONS:
NAC could improve pancreatic microvascular perfusion and alleviate the severity of sodium taurocholate-induced ANP, possibly representing a new therapeutic approach to prevent the progression of ANP.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Páncreas
/
Conductos Pancreáticos
/
Perfusión
/
Acetilcisteína
/
Sodio
/
Ácido Taurocólico
/
Infusiones Intravenosas
/
Factor Natriurético Atrial
/
Flujometría por Láser-Doppler
/
Pancreatitis Aguda Necrotizante
Tipo de estudio:
Estudio pronóstico
Límite:
Animales
Idioma:
Inglés
Revista:
Gut and Liver
Año:
2013
Tipo del documento:
Artículo
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