Prognostic factors in neuroendocrine cervical carcinoma
Obstetrics & Gynecology Science
;
: 116-122, 2016.
Artículo
en Inglés
| WPRIM
| ID: wpr-158473
ABSTRACT
OBJECTIVE:
To evaluate the clinical and pathologic factors associated with survival in patients with neuroendocrine cervical carcinoma (NECC).METHODS:
The records of 61 patients with NECC diagnosed between 2000 and 2014 at Seoul National University Hospital and the National Cancer Center were retrospectively reviewed. Kaplan-Meier and Cox regression methods were used for analyses.RESULTS:
Of the 61 patients, 67.2% were diagnosed at early stage (I to IIA) with a median age of 49 years. Of those, 78% underwent surgery and 75.6% received postoperative adjuvant treatment. For patients diagnosed at advanced stage, 60.0% received chemotherapy only and 25.0% received concurrent chemoradiation therapy. In the univariate analysis, advanced stage (77 vs. 40 months, P=0.013), tumor size ≥2 cm (133 vs. 47 months, P=0.002) and mixed tumor (101 vs. 34 months, P=0.004) were shown to be poor prognostic factors. In the multivariate analysis, tumor stage, tumor size and tumor homology were shown to be independent prognostic factors for overall survival. Of the total, 39.3% of the patients experienced recurrence, and 54.1% of the patients had metastasis. Of the patients diagnosed at early stage, 51.2% experienced recurrence.CONCLUSION:
Tumor stage, tumor size and tumor homology were found to be independent prognostic factors in patients with NECC. Even in patients diagnosed at early stage, recurrence and distant metastasis were frequently observed.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Recurrencia
/
Análisis Multivariante
/
Estudios Retrospectivos
/
Carcinoma de Células Pequeñas
/
Carcinoma Neuroendocrino
/
Quimioterapia
/
Seúl
/
Metástasis de la Neoplasia
Tipo de estudio:
Estudio observacional
/
Estudio pronóstico
/
Factores de riesgo
Límite:
Humanos
País/Región como asunto:
Asia
Idioma:
Inglés
Revista:
Obstetrics & Gynecology Science
Año:
2016
Tipo del documento:
Artículo
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