Clinicopathologic Analysis of the Liver Explant with Severe Hepatitis A Virus Infection
Korean Journal of Pathology
;
: S48-S52, 2011.
Artículo
en Inglés
| WPRIM
| ID: wpr-158727
ABSTRACT
The incidence of severe hepatitis A virus (HAV) infection has been increasing. However, clinicopathologic features of severe HAV infection that lead to liver transplantation (LT) have not been reported in Korea. We retrieved 16 LT cases with HAV infection during the last 3 years at Asan Medical Center, Seoul, Korea. Fifteen cases progressed to hepatic encephalopathy. Thirteen cases survived with or without complications, and three patients died of sepsis. The explanted liver showed massive or zonal necrosis with moderate to severe cholestasis. The zonal distribution of necrosis was frequently associated with endothelialitis of portal and/or central veins. Degenerative changes of hepatocytes were various in degree and distribution. Viral inclusions were suspected in two cases. Although HAV infection is usually confirmed by serological tests, significant venulitis of central and/or portal veins and viral inclusions, which are rarely observed, can suggest an HAV infection as a cause of massive hepatic necrosis of unknown mechanism.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Vena Porta
/
Venas
/
Pruebas Serológicas
/
Fluconazol
/
Encefalopatía Hepática
/
Colestasis
/
Incidencia
/
Trasplante de Hígado
/
Sepsis
/
Hepatocitos
Tipo de estudio:
Estudio diagnóstico
/
Estudio de incidencia
/
Estudio pronóstico
Límite:
Humanos
País/Región como asunto:
Asia
Idioma:
Inglés
Revista:
Korean Journal of Pathology
Año:
2011
Tipo del documento:
Artículo
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