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A Case of Gefitinib (Iressa(R))-associated Tumor Lysis Syndrome in Adenocarcinoma of the Lung / 영남의대학술지
Yeungnam University Journal of Medicine ; : 221-226, 2006.
Artículo en Coreano | WPRIM | ID: wpr-158975
ABSTRACT
The tumor lysis syndrome has been described as biochemical disturbances associated with rapid destruction of tumor cells and subsequent synchronized massive release of cellular breakdown products sufficient to overwhelm excretory mechanisms and the body's normal reutilization capacity. The cardinal signs of the tumor lysis syndrome are hyperkalemia, hyperphosphatemia, hypocalcemia and hyperuricemia. Gefitinib (Iressa) is an oral, selective epidermal growth factor receptor (EGFR) inhibitor that has activity in female, non-smoker and non-small cell lung cancer with an EGFR mutation. Gefitinib is a well tolerated drug with few side effects. It has been associated with skin rash, diarrhea, nausea, a decrease in liver function and interstitial lung disease. However, there is no prior report of the tumor lysis syndrome associated with gefitinib. We report a case of a 54 year-old woman who developed tumor lysis syndrome that might have been induced by gefitinib after the treatment of adenocarcinoma of lung with an EGFR mutation.
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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Adenocarcinoma / Síndrome de Lisis Tumoral / Enfermedades Pulmonares Intersticiales / Carcinoma de Pulmón de Células no Pequeñas / Hiperuricemia / Diarrea / Exantema / Hiperfosfatemia / Receptores ErbB / Hiperpotasemia Límite: Femenino / Humanos Idioma: Coreano Revista: Yeungnam University Journal of Medicine Año: 2006 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Adenocarcinoma / Síndrome de Lisis Tumoral / Enfermedades Pulmonares Intersticiales / Carcinoma de Pulmón de Células no Pequeñas / Hiperuricemia / Diarrea / Exantema / Hiperfosfatemia / Receptores ErbB / Hiperpotasemia Límite: Femenino / Humanos Idioma: Coreano Revista: Yeungnam University Journal of Medicine Año: 2006 Tipo del documento: Artículo