Mantle cell lymphoma presented as multiple lymphomatous polyposis: clinical review of 4 cases / 대한내과학회지
Korean Journal of Medicine
; : 413-422, 2000.
Article
en Ko
| WPRIM
| ID: wpr-160743
Biblioteca responsable:
WPRO
ABSTRACT
Multiple lymphomatous polyposis(MLP) is an interesting clinical entity of non-Hodgkin's lymphoma(NHL) and is defined as B-cell lymphoma characterized by the presence of multiple lymphomatous polyps along the gastrointestinal tract. Recently MLP has been considered as a variant form of mantle cell lymphoma(MCL). The median survival of patients with MCL is only 3 years, and none of the available conventional chemotherapy regimens appears curative. Encouraging results have been reported with high dose chemotherapy with autoSCT and alloSCT for its treatment. We introduce 4 cases of MLP diagnosed as MCL by morphologic and immunologic method. The common clinical findings of these cases were splenomegaly (4/4), multiple intraabdominal lymphadenopathy (4/4), and advanced stage (3/4) at presentation. The overall remission duration was relatively short (5-27 months) and three of four cases relapsed after conventional chemotherapy or autologous stem cell transplant. Our report suggests that MCL presented as MLP is a high risk subgroup of NHL and more aggressive approach may be needed for cure.
Palabras clave
Texto completo:
1
Índice:
WPRIM
Asunto principal:
Pólipos
/
Esplenomegalia
/
Células Madre
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Linfoma de Células B
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Linfoma de Células del Manto
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Tracto Gastrointestinal
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Quimioterapia
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Enfermedades Linfáticas
/
Linfoma
Límite:
Humans
Idioma:
Ko
Revista:
Korean Journal of Medicine
Año:
2000
Tipo del documento:
Article